![]() In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. 8MM School of Pharmacy, MM University, Sadopur-Ambala, Indiaįungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny.7Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.6Chitkara College of Pharmacy, Chitkara University, Rajpura, India.5College of Chemistry and Chemical Engineering, Hubei University, Hubei, China.4Innovation, Incubation and Industry (i-cube) Laboratory, Techno India NJR Institute of Technology, Udaipur, India. ![]() 3CHRIST (Deemed to be University), Bangalore, India.2School of Pharmaceutical Sciences, RIMT University, Mandi Gobindgarh, Punjab, India.1Department of Radiation Oncology, University of Kansas Medical Center, Kansas, KS, United States.Rishi Man Chugh 1, Pooja Mittal 2, Namratha MP 3, Tanu Arora 1, Tanima Bhattacharya 4,5*, Hitesh Chopra 6, Simona Cavalu 7* and Rupesh K.
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